Synthesis of an Isomeric Nucleoside Enantiomers of 1,3-bis(1'-deoxy-β-ribofuranose-2'-yl)-thymine

Zhi Dong Sun; Zi Wen Gong; Chen Hu; Hai Yang Huang; Xi Chen; Qiang Xiao

doi:10.4028/www.scientific.net/AMR.1094.49

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 1094Synthesis of an Isomeric Nucleoside Enantiomers of...

Synthesis of an Isomeric Nucleoside Enantiomers of 1,3-bis(1'-deoxy-β-ribofuranose-2'-yl)-thymine

Abstract:

The enantiomer isomeric nucleosides of 1,3-bis (1'-deoxy-β-ribofuranose-2'-yl)-thymine were synthesized from 1-deoxy-5-O-triphenylmethyl-ribose in high yield and selectivity. The key step is the coupling of 1-deoxy-5-O-triphenylmethyl-2,3-O-cyclosulphate-ribose and thymine using cesium carbonate as the base.

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Periodical:

Advanced Materials Research (Volume 1094)

Pages:

49-52

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.1094.49

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Online since:

March 2015

Authors:

Zhi Dong Sun, Zi Wen Gong, Chen Hu, Hai Yang Huang, Xi Chen*, Qiang Xiao

Keywords:

Cesium Carbonate, Cyclic Sulfate, Isomeric Nucleoside, Synthesis

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