The Improved Process for the Preparation of Iloperidone

Zhen Hua Shang; Qian Qian Chu; Jing Ha; Chen Hong An; Pan Wang

doi:10.4028/www.scientific.net/AMR.1094.57

Paper Titles

Synthesis and Characterization of a Cascaded Chromogenic Enzyme Substrate
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Synthesis and Characterization of a Dumbbell-Shaped Polyrotaxane Based on Polytetrahydrofuran bis(3-aminopropyl) Terminated and α-Cyclodextrins Using Polyamidoamine (PAMAM) Dentrimers as Bulky Stoppers
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Synthesis of an Isomeric Nucleoside Enantiomers of 1,3-bis(1'-deoxy-β-ribofuranose-2'-yl)-thymine
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Synthesis of Carbohydrate-Conjugated Flavone Derivatives
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The Improved Process for the Preparation of Iloperidone
p.57

Preparation of Sulfur-Free Exfoliated Graphite in the Graphite-HClO₄-CH₃COOH Systerms
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Preparation of Chitosan Nanospheres by Miniemulsion Crosslinking Method
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Kelvin Probe Force Microscopy Study of the Photogeneration of Surface Charges in Polymer Photovoltaic Film
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Gold Catalysts on TiO₂-Modified Silica Gel for the Selective Cyclopentane Oxidation to Cyclopentanone
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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 1094The Improved Process for the Preparation of...

The Improved Process for the Preparation of Iloperidone

Abstract:

The main object of the present invention is to provide an improved process for the preparation of Iloperidone, which would be more simple, economical and easy to implement on large scale preparation. In this paper, 1,3-difluorobenzene and 1-(4-hydroxy-3-methoxyphenyl) ethanone are starting materials. And then tartaric acid is added. The key intermediate (Z)-4-(2,4-difluorobenzoyl) piperidine oxime is obtained through stereoselectivity. With the key intermediate and 1-(4-(3-chloropropoxy)-3-methoxyphenyl) ethanone, the target product is obtained directly under the condition of catalyst.

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Periodical:

Advanced Materials Research (Volume 1094)

Pages:

57-60

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.1094.57

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Online since:

March 2015

Authors:

Zhen Hua Shang*, Qian Qian Chu, Jing Ha, Chen Hong An, Pan Wang

Keywords:

Iloperidone, Preparation, Single Crystal Diffraction

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