Study on Preparation Technology Optimization of Sultamicillin Tosilate-β-Cyclodextrin

Abstract:

To study the process conditions for preparing sultamicillin tosilate β-cyclodextrin inclusion.Method: Choose the usage ration of sultamicillin tosilate with β-cyclodextrin, the inclusion temperature and the time of reaction as the main factors, and use the inclusion yield as evaluated indicators and the process condition to conduct the L⁹ (3⁴) orthogonal experiment Optimization Pack sultamicillin tosilate.Outcome: The optimum inclusion process condition: molar ratio of the sultamicillin tosilate with β-cyclodextrin is 1:8, inclusion temperature is 47°C, inclusion time is 40 minutes.Conclusion: The process condition of using β-cyclodextrin inclusion to inconcluse sultamicillin tosilate is feasible, effective, and of applicative value.

• Periodical: Advanced Materials Research (Volumes 1120-1121)
• Pages: 873-876
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1120-1121.873
• Online since: July 2015
• Authors: Xiang Qun Xu, Nian Hong, Jie Yang, You Quan Zhong, Lin Cheng*
• Keywords: Inclusion Process, Orthogonal, Sultamicillin Tosilate, β-Cyclodextrin

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