Microbial Transformation of Glycyrrhetinic Acid by Colletotrichum lini AS3.4486

Chao Jun He; Yu Min Yang; Kong Yang Wu

doi:10.4028/www.scientific.net/AMR.1120-1121.877

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 1120-1121Microbial Transformation of Glycyrrhetinic Acid by...

Microbial Transformation of Glycyrrhetinic Acid by Colletotrichum lini AS3.4486

Abstract:

The biotransformation of 18β-glycyrrhetinic acid by Colletotrichum lini AS3.4486 was investigated. The conversion reaction was carried out for 72h, and the sole product was isolated by column chromatography and elucidated as 7β,15α-dihydroxy-18β-glycyrrhetinic acid by HR-ESI-MS, ¹H-NMR , ¹³C-NMR and single–crystal X-ray diffraction. The crystal of the conversion product belongs to orthorhombic, space group P2₁2₁2₁ with 11.828(1), 13.213(2), 19.606(2) Å , V = 3064.0 Å³, Z = 4. This study povides a new method for the synthesis of 7β,15α-dihydroxy-18β-glycyrrhetinic acid.

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Periodical:

Advanced Materials Research (Volumes 1120-1121)

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877-881

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https://doi.org/10.4028/www.scientific.net/AMR.1120-1121.877

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Online since:

July 2015

Authors:

Chao Jun He*, Yu Min Yang, Kong Yang Wu

Keywords:

18β-Glycyrrhetinic Acid, Colletotrichum lini AS3.4486, Microbial Transformation

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