Preparation of Aspirin-β-Cyclodextrin Inclusion Complex by Grinding Method

Xiang Qun Xu; Nian Hong; Jing Wen Zheng; Bing Bing Guo; Lin Cheng

doi:10.4028/www.scientific.net/AMR.1120-1121.882

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Preparation of Aspirin-β-Cyclodextrin Inclusion Complex by Grinding Method

Abstract:

To study the process conditions for preparing aspirin β-cyclodextrin inclusion.Method: Choose the usage ration of aspirin with β-cyclodextrin and the time of reaction as the main factors, and use the inclusion yield as evaluated indicators and the process condition to conduct orthogonal experiment Optimization Pack aspirin.Outcome: The optimum inclusion process condition: molar ratio of the aspirin with β-cyclodextrin is 1:3, inclusion time is 60 minutes.Conclusion: The process condition of using β-cyclodextrin inclusion to inconcluse aspirin is feasible, effective, and of applicative value.