In this paper, the preparation of amphiphobic CaCO3-wood composite by reaction of CaCl2 and Na2CO3 in wood through double-diffusive method in the presence of perfluorooctane surfapropyl betaine (DF-921) is demonstrated. The properties of synthesized CaCO3-wood composite were investigated by the contact angle analysis, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscope (SEM). The mechanical properties of the product were tested. The experimental results suggested that a much higher properties performance for the wood-based composite with modified CaCO3. The surface of the new product exhibited the amphiphobic property.