Pollution with Cr (VI) and Ni (II) waste water is frequently encountered together in practice, and the ferrite process carves out a new way for the treatment of wastewater contaminated by heavy metals. The purpose of this study is to investigate the treatment of Cr (VI) and Ni (II) wastewater by the ferrite process.In this paper, the ferrite process of Cr (VI) and Ni (II) synthetic solution by hydrothermal reaction and its technological parameters was sdudied. The most optimum reaction conditions were explored: pH=9.0, temperature=70°C, stirring time=40min, stirring speed=120 rpm. Leaching toxicity of heavy metals from Ni–Cr ferrite prepared in the experiment was much lower than the regulated limit of Toxicity Characteristic Leaching Procedure (TCLP), indicating that Ni–Cr ferrite had a better chemical stability. Therefore, the ferrite process is a feasible method with respect to the removal of chromium and nickel ions from wastewater.