A pH/Temperature-Sensitive Semi-IPN Bead for Drug Release Carrier

Abstract:

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A series of pH/temperature sensitive hydrogel beads with semi-interpenetrating polymer network (semi-IPN), composed of sodium alginate and poly(N-acryloylglycinate) were prepared as drug delivery carrier. In pH=2.3 phosphate buffer solution (PBS), the release amount of indomethacin incorporated into the beads was about 9% within 610 min, while this value approached to 68% in pH=7.4 PBS. The release rate of indomethacin was higher at 37 than that at 20 . In addition, the release amount of indomethacin was increased with increasing poly(N-acryloylglycinate) content. These results suggest that the stimuli-sensitive beads have the potential to be used as an effective pH/temperature delivery system in bio-medical fields.

Info:

Periodical:

Advanced Materials Research (Volumes 148-149)

Edited by:

Xianghua Liu, Zhengyi Jiang and Jingtao Han

Pages:

1449-1452

DOI:

10.4028/www.scientific.net/AMR.148-149.1449

Citation:

K. L. Deng et al., "A pH/Temperature-Sensitive Semi-IPN Bead for Drug Release Carrier", Advanced Materials Research, Vols. 148-149, pp. 1449-1452, 2011

Online since:

October 2010

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Price:

$35.00

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