A pH/Temperature-Sensitive Semi-IPN Bead for Drug Release Carrier

Kui Lin Deng; Yu Bo Gou; Jian Zuo; Li Rong Dong; Qian Li; Ting Gao

doi:10.4028/www.scientific.net/AMR.148-149.1449

Paper Titles

Nanofibrous Membrane of Silk Fibroin/Cellulose Acetate Blend for Heavy Metal Ion Adsorption
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Synthesis of CuIn_xGa_1-xSe₂ Powder by High-Pressure Stirring Solvothermal Method
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Influence of External Factors on Anisotropic Growth Habit of ZnO Crystal
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Effects of Synthesis Parameters on Hydrothermal Synthesis of NaA Zeolite
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A pH/Temperature-Sensitive Semi-IPN Bead for Drug Release Carrier
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Synthesis of HfC Powders by Carbothermal Reduction of Modified Hafnium Alkoxide Precursors
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Optimum Design of a Kind of Split Type Compound Vessel Used in Ultrahigh Pressure Technology
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Study on the Shape Memory Effect of Styrene Copolymer
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Synthesis, Characterization and Photocatalytic Activities of Bismuth Vanadate by Facile Co-Precipitation Method
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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 148-149A pH/Temperature-Sensitive Semi-IPN Bead for Drug...

A pH/Temperature-Sensitive Semi-IPN Bead for Drug Release Carrier

Abstract:

A series of pH/temperature sensitive hydrogel beads with semi-interpenetrating polymer network (semi-IPN), composed of sodium alginate and poly(N-acryloylglycinate) were prepared as drug delivery carrier. In pH=2.3 phosphate buffer solution (PBS), the release amount of indomethacin incorporated into the beads was about 9% within 610 min, while this value approached to 68% in pH=7.4 PBS. The release rate of indomethacin was higher at 37 than that at 20 . In addition, the release amount of indomethacin was increased with increasing poly(N-acryloylglycinate) content. These results suggest that the stimuli-sensitive beads have the potential to be used as an effective pH/temperature delivery system in bio-medical fields.