Taking bridge pile of high speed railway as background, resistance to chloride ion penetration of high performance concrete is studied. Theoretical analysis and experimental research of chloride ion penetration are carried out for double-doped mineral (fly ash and slag powder) concrete, C35 single mineral and preservative double-doped concrete, and C35 two kinds of minerals and preservative composite concrete. In addition, the test results are compared and analyzed. Study results show: chloride ion penetration grade of double-doped mineral concrete (C35, C40, C45 and C50) is very low. Resistances to chloride ion penetration of C35 single mineral and preservative double-doped concrete are all poor overall, so the scheme is infeasible. By performance comparison of resistance to chloride ion penetration, C35 two kinds of minerals and solid preservative composite concrete is obviously better than C35 two kinds of minerals and liquid preservative composite concrete , meanwhile obviously better than C35 double-doped mineral concrete, and very close to C50 double-doped mineral concrete. And, it can meet resistance to chloride ion penetration requirement under the corrosion environments along the high speed railway line and can be used as high performance concrete to resist chloride salt.