With the development of science and technology, silk fabric becomes more and more colorful. On the one hand, hand-painted silk fabrics have unparalleled appearance reflecting the designer’s concept, on the other hand high fashion is one of high value-added products. High fashion design needs more unique fabric and the hand-painted silk fabric is just the right choice. In the West, designers attach more importance to developing silk fabric in high fashion design extensively and innovatively; while in China the high fashion design is still holding a backward position. Through studying the relationship of hand-painted silk fabric and high fashion in China, we can forecast the trend of hand-painted silk in high fashion design effectively, and at the same time promote the development of high fashion design.