Preparation, Characterization and Properties Evaluation of Buprofezin Nanocomposites Obtained by Polyelectrolytes Assembly

Abstract:

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Buprofezin (BPF) microcrystals were directly encapsulated with nature polysaccharides chitosan (CHI) and sodium alginate (ALG) through layer-by-layer (LbL) self-assembly. The coated colloids were characterized using confocal laser scanning microscopy (CLSM) and scanning electron microscopy (SEM). The surface of the coated microcrystal was smoothened and the coating was uniform. Different concentrations of the ALG, CHI, BPF and CaCl2 were selected as the influencing factors, and then, the microcapsules were optimized by orthogonal experiment. The size distribution of microcapsules was determined by Laser Diffraction Size Analyzer. It showed statistically normal distribution. The average diameter of BPF was 1.5m. The encapsulation efficiency of the BPF loaded microparticles was about 67.2±0.73%. The drug loading content was about 66.7±0.31% after encapsulated. The in vitro release experiments revealed that the polyelectrolytes prolonged the release time of the encapsulated BPF microcrystals.

Info:

Periodical:

Advanced Materials Research (Volumes 183-185)

Edited by:

Yanguo Shi and Jinlong Zuo

Pages:

1677-1681

DOI:

10.4028/www.scientific.net/AMR.183-185.1677

Citation:

Z. Zhang et al., "Preparation, Characterization and Properties Evaluation of Buprofezin Nanocomposites Obtained by Polyelectrolytes Assembly", Advanced Materials Research, Vols. 183-185, pp. 1677-1681, 2011

Online since:

January 2011

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$35.00

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