Study on Reversibility of Genetic Toxicity of TDI in Mice

Miao Yu; Yu Bin Ji

doi:10.4028/www.scientific.net/AMR.183-185.905

Paper Titles

Preliminary Study on Extracting Technique and Biological Activity of Fucoidin in Undaria pinnatifida
p.887

Effects of Substrate Concentration and pH on H₂-Producing Capacity with Clostridium R33 sp.nov.
p.891

Improvement of Anaerobic Operation and Isolation Culture on Hydrogen-Producing and Fermentative Bacteria
p.895

The Determination of Nitrate Reductase Activity of Leaves to the Dominant Species in Forest Community of Northern Aspect of Changbai Mountains
p.900

Study on Reversibility of Genetic Toxicity of TDI in Mice
p.905

Chemical Composition and Antimicrobial Activity of Essential Oil from Amomum Tsao-Ko Cultivated in Yunnan Area
p.910

Chemical Composition and Antibacterial Activity of Essential Oil from the Basil Cultivated in Heilongjiang
p.915

Chemical Composition of Antibacterial Activity of Essential Oil from Monarda citriodora Flowers
p.920

Biosynthesis of Poly-β-Hydroxybutyrate as New Material of Food Packing by Various Strains of Methanotrophs from Methane
p.924

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Study on Reversibility of Genetic Toxicity of TDI in Mice

Abstract:

Study on whether genetic toxicity of toluene diisocyanate (TDI) is reversible. This paper detected Chromosomal aberrations and content of RNA & DNA. Chromosome aberration rate and the RNA/DNA ratio of TDI 1/4LC50 and 1/2 LC50 dosing exposure group were higher than negative control group significantly (P<0.01). There was no significant difference between 1/4LC50 and 1/2LC50 (P>0.05).The results showed that the damage of TDI on chromosomes and DNA was repairable, but can not be repaired completely.