Study on Reversibility of Genetic Toxicity of TDI in Mice
Study on whether genetic toxicity of toluene diisocyanate (TDI) is reversible. This paper detected Chromosomal aberrations and content of RNA & DNA. Chromosome aberration rate and the RNA/DNA ratio of TDI 1/4LC50 and 1/2 LC50 dosing exposure group were higher than negative control group significantly (P<0.01). There was no significant difference between 1/4LC50 and 1/2LC50 (P>0.05).The results showed that the damage of TDI on chromosomes and DNA was repairable, but can not be repaired completely.
Yanguo Shi and Jinlong Zuo
M. Yu and Y. B. Ji, "Study on Reversibility of Genetic Toxicity of TDI in Mice", Advanced Materials Research, Vols. 183-185, pp. 905-909, 2011