Study on Reversibility of Genetic Toxicity of TDI in Mice

Abstract:

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Study on whether genetic toxicity of toluene diisocyanate (TDI) is reversible. This paper detected Chromosomal aberrations and content of RNA & DNA. Chromosome aberration rate and the RNA/DNA ratio of TDI 1/4LC50 and 1/2 LC50 dosing exposure group were higher than negative control group significantly (P<0.01). There was no significant difference between 1/4LC50 and 1/2LC50 (P>0.05).The results showed that the damage of TDI on chromosomes and DNA was repairable, but can not be repaired completely.

Info:

Periodical:

Advanced Materials Research (Volumes 183-185)

Edited by:

Yanguo Shi and Jinlong Zuo

Pages:

905-909

DOI:

10.4028/www.scientific.net/AMR.183-185.905

Citation:

M. Yu and Y. B. Ji, "Study on Reversibility of Genetic Toxicity of TDI in Mice", Advanced Materials Research, Vols. 183-185, pp. 905-909, 2011

Online since:

January 2011

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$35.00

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