Evaluation of Native and Pregelatinized Arrowroot (Maranta Arundinacea) Starches as Disintegrant in Tablet Formulation

Abstract:

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The purpose of this study was to investigate the disintegrating properties of native arrowroot starch and pregelatinized arrowroot starch in comparison with corn starch and sodium starch glycolate (Explotab®). Tablets were prepared by direct compression. The tablet formulations contained dibasic calcium phosphate as filler and magnesium stearate as lubricant. Each starch at various concentrations between 2-10 % w/w was used in formulation as disintegrant. The swelling volume and weight of starches and disintegration time of tablets were evaluated. At 2% w/w concentration of starch, the pregelatinizaed starch provided disintegration time faster than the native starch (2.5 times). The disintegration time of 2% w/w pregelatinized arrowroot starch was comparable to Explotab and faster than that of native starch. The disintegration time of native starch at the concentration of 4, 6 and 10 %w/w was comparable to that of corn starch and Explotab®. Native arrowroot starch and pregelatinized arrowroot starch could be used as effective disintegrants in tablet formulation.

Info:

Periodical:

Advanced Materials Research (Volumes 197-198)

Edited by:

Huaiying Zhou, Tianlong Gu, Daoguo Yang, Zhengyi Jiang, Jianmin Zeng

Pages:

127-130

DOI:

10.4028/www.scientific.net/AMR.197-198.127

Citation:

V. Patomchaiviwat et al., "Evaluation of Native and Pregelatinized Arrowroot (Maranta Arundinacea) Starches as Disintegrant in Tablet Formulation", Advanced Materials Research, Vols. 197-198, pp. 127-130, 2011

Online since:

February 2011

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Price:

$35.00

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