Cross-coupling Reaction of Grignard Reagents with Alkyl Halides Catalyzed by Green, Economical Copper Bromide Catalyst

Abstract:

For the first time a systematic research on the catalytic activity of CuX_n (X=Cl, Br, I; x=1,2) for the cross-coupling reaction of alkyl halides with Grignard reagents was carried out and environmentally friendly, economical CuBr₂ showed highest catalytic activity among the catalyst. The conditions of the cross-coupling reaction were studied. The suitable amount of catalyst, reaction temperature and time are 0.3% mol (based on alkyl halide), 67°C (reflux), 6 h, respectively. Under the optimal conditions, the yields of the cross-coupling could reach up to 93%. Moreover, Grignard reagent with an electron-rich group reacted rapidly and with an electron-withdrawing group reacted sluggishly.

• Periodical: Advanced Materials Research (Volumes 233-235)
• Pages: 1119-1122
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.233-235.1119
• Online since: May 2011
• Authors: Zhi Qun Dai, Zhi Yong Zhang, Wei Wei Zhang, Ben Mei Wei
• Keywords: Catalyzed, Copper Bromide, Cross-Coupling, Grignard Reagent

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