Identifying Time-Dependent Drug Diffusion Parameters in the Cylindrical Tube by Optimal Algorithm

Article Preview

Abstract:

First, a FD scheme based on a polar-coordinate diffusion optimization problem is derived. Next, an optimization algorithm to compute the partial derivatives is proposed. Third, the procedure for the time-dependent drug diffusion parameters is given. Finally, the numerical result shows the validity of the optimal method based on FD to extract the effective time-dependent drug diffusivity.

You might also be interested in these eBooks

Info:

Periodical:

Advanced Materials Research (Volumes 236-238)

Pages:

2118-2121

Citation:

Online since:

May 2011

Export:

Price:

Permissions CCC:

Permissions PLS:

Сopyright:

© 2011 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

[1] J.C. FU, C. Hagemeier and D. L. Moyer, an unified mathematical model for diffusion from drug-polyner composite tablets, J. biomed matter. Res. 10 (1976) 743-758.

DOI: 10.1002/jbm.820100507

Google Scholar

[2] M. Grassi and G. Grassi, Mathematical modelling and controlled drug delivery: matrix systems, Current Drug Delivery 2(2005) 97-116.

DOI: 10.2174/1567201052772906

Google Scholar

[3] G.J. Crawford, C.R. Hicks, X.Lou, S. Vijayasekaran, D Tan, T.V. Chirila, I.J. Constable, The Chirila Ker-atoprostesis: Phase I human clinical trials, Ophthalmology 109(2002) 883-889

DOI: 10.1016/s0161-6420(02)00958-2

Google Scholar

[4] W. R. Lee, S. Wang, K. L. Teo. An optimization approach to a finite dimensional parameter estimation problem in semiconductor device design, Journal of Computational Physics(1999),vol 156, 241-256.

DOI: 10.1006/jcph.1999.6358

Google Scholar

[5] K. Asaokaa and S. Hirano, diffusion coefficient of water through dental composite resin, biomaterials 24(2003) 975-979

DOI: 10.1016/s0142-9612(02)00435-0

Google Scholar