Inhibition Mechanism and Kinetic Model for Ozagrel on Mushroom Tyrosinase

Abstract:

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This investigation shows that ozagrel, an antithrombotic drug, can inhibit mushroom tyrosinase well. The IC50 value was 3.45 mmol/L. Ozagrel was estimated to be a reversible mixed-type inhibitor of mushroom tyrosinase by Lineweaver-Burk plots. The inhibition kinetics has been studied by using the kinetic method of the substrate reaction described by Tsou. The constants of tyrosinase and tyrosinase-substrate complex inhibited by 1.0 mmol/L ozagrel have been determined to be 87.28 and 66.07 µmol/L, respectively.

Info:

Periodical:

Advanced Materials Research (Volumes 236-238)

Edited by:

Zhong Cao, Yinghe He, Lixian Sun and Xueqiang Cao

Pages:

2913-2916

DOI:

10.4028/www.scientific.net/AMR.236-238.2913

Citation:

B. L. Shu et al., "Inhibition Mechanism and Kinetic Model for Ozagrel on Mushroom Tyrosinase", Advanced Materials Research, Vols. 236-238, pp. 2913-2916, 2011

Online since:

May 2011

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Price:

$35.00

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