In this paper, a 9-storey Benchmark frame model was used to analyze the response of joints due to sudden column loss. On the basis of the substructure model, the static and dynamic nonlinear analyses were conducted seriatim using the alternative path method. It is found that the removals of the ground columns bring high-level joint moments and mild increasing of axial forces. In particular, the removal of side column with pin-ended connection results in the largest vertical displacement of adjacent joint and increase the flexural demands to the next joint. For this model, the most critical case appears at the failure of hinged side column, the next is the rigid side column.