Study on the Interaction of Fluorescent Probe 2-(2'-Chloro Phenyl)-5-(2'-Hydroxyl Phenyl)1,3,4-Oxadiazole with DNA

Mei Ding; Ying Jie Lei; Fang Xu; Ou Yang Jie

doi:10.4028/www.scientific.net/AMR.284-286.2392

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 284-286Study on the Interaction of Fluorescent Probe...

Study on the Interaction of Fluorescent Probe 2-(2'-Chloro Phenyl)-5-(2'-Hydroxyl Phenyl)1,3,4-Oxadiazole with DNA

Abstract:

The interaction between self-synthesized fluorescent probe 2-(2'- Chloro phenyl)- 5- (2'- hydroxyl phenyl)1,3,4-oxadiazole (HOXD) and Calf thymus DNA was studied using UV absorption spectra and fluorescence quenching spectra．The data of fluorescence quenching of HOXD by DNA were analyzed according to Stern-Volmer equation and Lineweaver-Burk double-reciprocal equation．The results indicated that the fluorescence quenching of HOXD might be static one attributed to the formation of adduct from HOXD and DNA, which was confirmed by the data of temperature effect experiment. Further results presented in the paper showed that intercalation binding might be the interaction mode between HOXD and DNA.

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Periodical:

Advanced Materials Research (Volumes 284-286)

Pages:

2392-2396

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.284-286.2392

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Online since:

July 2011

Authors:

Mei Ding, Ying Jie Lei, Fang Xu, Ou Yang Jie

Keywords:

2-(2'-Chloro Phenyl)-5-(2'-Hydroxyl Phenyl)-1,3,4-Oxadiazole, DNA, Fluorescence Quenching, Interaction

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