The aim of this article is to study the texture features of cingulum in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) based on magnetic resonance images, and explore the texture differences derived from different gender among each group. Texture analysis was performed on 7 AD patients, 14 MCI patients and 11 normal controls (NC). Texture features extracted from gray level co-occurrence matrix and run-length matrix were analyzed between each two groups. The results showed that texture features of the anterior cingulum had significant differences in the multiple comparisons and features of the posterior cingulum had significant differences between AD and MCI group as well as AD and NC group. There were significant differences between AD and MCI group as well as AD and NC group in male’s cingulum. While in female’s cingulaum, the differences were founded between AD and NC group. The results indicated that the pathological changes in cingulum could be reflected by texture features and the pathological changes may be different in the two genders.