Hydrothermal Synthesis of Hydroxyapatite Urchins and its Drug Release Property

Li Xia Yang; Quan Wen Liu; Tao Liang; Jia Jun Yin; Lai Fen Qin; Ying Ying Tang; Xiang Peng Jiang

doi:10.4028/www.scientific.net/AMR.311-313.1681

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Design and Research on Mechanical Properities of New Type Low Modulus Biomedical Metastable β Titanium Alloy
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Energy Conservation Study during Abrasive Water Jet Cutting
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Error Correction of Theory Model in Process-Stress Accelerated Test
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Hydrothermal Synthesis of Hydroxyapatite Urchins and its Drug Release Property
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Study for Seeking Optimal Mix Proportion of Resin Concrete
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Fabrication of Polycaprolactone/Chitosan Scaffolds by Freeze-Solvent Extraction Method
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The Microstructure and Tensile Property of Mg-Zn-Ca-Zr Alloy Sheet Coated with HA and its Antihemolytic Ability
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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 311-313Hydrothermal Synthesis of Hydroxyapatite Urchins...

Hydrothermal Synthesis of Hydroxyapatite Urchins and its Drug Release Property

Abstract:

Hydroxyapatite (HAP) urchins were synthesized by a facile hydrothermal method using calcium nitrate, ammonium dihydrogen phosphate, diamine tetraacetic acid disodium salt as complexing agent and ethonalamine as alkaline source. The influence of hydrothermal time on crystallinity and morphology of HAP have been investigated. The results indicate that well-crystallized HAP urchins can be synthesized at 180°C for 24h. SEM images show a large area of urchin-like microspheres consisted of a number of ribbons with lengths ranging from 2 to 5μm. Based on XRD and SEM results, the formation mechanism of HAP crystals has been discussed. A typical anti-inflammatory drug, ibuprofen, was used for drug loading, and the release behaviors of ibuprofen in a simulated body fluid (SBF) were studied. The results indicate that HAP urchins showed a favorable sustained release property for ibuprofen.