Fabrication of Polycaprolactone/Chitosan Scaffolds by Freeze-Solvent Extraction Method
The polycaprolactone (PCL)/chitosan (CS) scaffolds were prepared by the freeze-solvent extraction method using glacial acetic acid with little water as a common blend system. The effect of different solvents on the crystallinity, the morphology, the structure and the mechanical properties of the scaffolds was studied. The results indicate that alkaline solvent favors the deposition of CS, solvent extraction in the frozen condition perfects the crystal of PCL and improves the crystallinity of PCL/CS scaffolds, in the mean while, the compression property enhances. The porosity of PCL/CS reaches 81%, when immersed in water solvent.
X. F. Xiao et al., "Fabrication of Polycaprolactone/Chitosan Scaffolds by Freeze-Solvent Extraction Method", Advanced Materials Research, Vols. 311-313, pp. 1695-1698, 2011