A novel water-compatible hypercrosslinked resin modified by p-aminophenol was synthesized with chloromethylated polystyrene and p-aminophenol by Friedel-Crafts reaction. The objective of this work was to study the adsorption performances for salicylic acid onto p-aminophenol resin. The results showed that the adsorption capacity of salicylic acid onto p-aminophenol resin was superior to XAD-4 resin. It is seen that the maximum adsorption capacity is observed at pH of 3.0. It was found the adsorption dynamics obeyed the pseudo-first-order rate equation and the intra-particle diffusion was the rate-limiting step. The maximum adsorption capacity of salicylic acid for p-aminophenol resin was measured to be 283.7 mg/g with the equilibrium concentration at 404.6mg/L. The micropore structure, the pore diameter of p-aminophenol resin, the hydrogen bond between p-aminophenol resin and salicylic acid bring the larger adsorption capacity.