A new three-dimensional (3D) nonlinear guidance law is proposed and developed for bank-to-turn (BTT) with motion coupling. First of all, the 3D guidance model is established. In detail, the line-of-sight (LOS) rate model is established with the vector description method, and the kinematics model is divided into three terms of pitching, swerving and coupling, then by using the twist-based method, the LOS direction changing model is built for designing the guidance law with terminal angular constraints. Secondly, the 3D guidance laws are designed with Lyapunov theory, corresponding to no terminal constraints and terminal constraints, respectively. And finally, the simulation results show that the proposed guidance law can effectively satisfy the guidance precision requirements of BTT missile.