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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 322Preparation of Biocompatible Micelles as Drug...

Preparation of Biocompatible Micelles as Drug Delivery via RAFT Polymerization

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Abstract:

Block copolymers D,L-Polylactide-b-poly(poly(ethylene glycol) methyl ether acrylate) (D,L- P(LA)-b-P(PEGMA)) were prepared via ring-opening polymerization and reversible addition fragmentation chain transfer (RAFT) polymerization. The block polymers generated in the reaction reveal the living behavior with the molecular weight increasing with time. The copolymer D,L-P(LA)200-b-P(PEGMA)₂₂₅was synthesized successfully with D,L-P(LA) macro-RAFT agent, and was self-assembled in an aqueous environment, leading to the formation of self-assembly micelles. A distinct critical micelle concentration (CMC) was observed of the self-assembly system. The size of it was characterized by both DLS and TEM.

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Advanced Research on Material Science, Environmental Science and Computer Science

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Periodical:

Advanced Materials Research (Volume 322)

Pages:

219-223

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.322.219

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Online since:

August 2011

Authors:

Lian Lai Cui, Tao Yu, Xin Tan, Yue Zhao, Jian Ping Li, Ling Zhang

Keywords:

Biocompatible, Drug Delivery, Micelle, Reversible Addition Fragmentation Chain Transfer (RAFT)

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© 2011 Trans Tech Publications Ltd. All Rights Reserved

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