Preparation of Biocompatible Micelles as Drug Delivery via RAFT Polymerization

Abstract:

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Block copolymers D,L-Polylactide-b-poly(poly(ethylene glycol) methyl ether acrylate) (D,L- P(LA)-b-P(PEGMA)) were prepared via ring-opening polymerization and reversible addition fragmentation chain transfer (RAFT) polymerization. The block polymers generated in the reaction reveal the living behavior with the molecular weight increasing with time. The copolymer D,L-P(LA)200-b-P(PEGMA)225 was synthesized successfully with D,L-P(LA) macro-RAFT agent, and was self-assembled in an aqueous environment, leading to the formation of self-assembly micelles. A distinct critical micelle concentration (CMC) was observed of the self-assembly system. The size of it was characterized by both DLS and TEM.

Info:

Periodical:

Edited by:

Helen Zhang and David Jin

Pages:

219-223

DOI:

10.4028/www.scientific.net/AMR.322.219

Citation:

L. L. Cui et al., "Preparation of Biocompatible Micelles as Drug Delivery via RAFT Polymerization", Advanced Materials Research, Vol. 322, pp. 219-223, 2011

Online since:

August 2011

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Price:

$35.00

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