The degradation of neoprene often occurs as a slow and gradual process and it is cannot be used abruptly. In order to keep the safety of equipments and people, it is important to consider the development of such process to correctly estimate its service life. The heat seawater method was designed and the accelerated aging tests of the neoprene were carried in laboratory. The tearing strength of the neoprene in aging time was investigated. The rule of tearing strength and aging time was studied. The service life prediction function of the neoprene was established and service life at 25°C was estimated based on the index of tearing strength. The result shows that tearing strength of the neoprene decreases in exponential form with aging time, and the service life of the neoprene used in sea water at 25°C is 29.79 years.