Bioactivity and Biocompatibility of Na2O-K2O-CaO-MgO-SrO-B2O3-P2O5 Borophosphate Glass
A novel Na2O-K2O-CaO-MgO-SrO-B2O3-P2O5 borophosphate glass is prepared by melting method. The thermal properties have been examined by differential thermal analysis (DTA) and viscosity measurement. The bioactivity of the glass is measured via soaking the glass in the SBF solution at 37 °C for different time. The reaction of the glass in the SBF solution is characterized by XRD, FTIR and SEM. The results indicate that the carbonate hydroxyapatite deposit on the glass in less than 7 days. Cell attachment, spreading and proliferation on the glass is determined by MTT [3-(4, 5-Dimethylthiazol-2-yl)-2, 5-Diphenyltetrazolium Bromide] assay method using Human osteosarcoma MG-63 cells. The borophosphate glass fiber is also drawn and the tensile strength is measured. The results suggest the borophosphate glass has a good potential to be a scaffold material for bone tissue engineering.
Yun-Hae Kim, Prasad Yarlagadda, Xiaodong Zhang and Zhijiu Ai
K. Zheng et al., "Bioactivity and Biocompatibility of Na2O-K2O-CaO-MgO-SrO-B2O3-P2O5 Borophosphate Glass", Advanced Materials Research, Vols. 335-336, pp. 1250-1256, 2011