Coal-water slurry （CWS）dispersant is a key to prepare fine coal-water slurry. A novel amphoteric polycarboxylic (AmPC) dispersant for CWS was copolymerized in aqueous solution by comonomers methacrylate polyglycol monoester (PA), propylene sulfur sodium (SAS) and cationic comonomer methacryloyloxy ethyl trimethylammonium chloride(DMC).Methacrylate polyglycol monoester was prepared by direct esterifying with methacrylate acid (AA) and polyethylene glycol (PEG) in our laboratory. And then, The molecule structure of amphoteric polycarboxylic dispersant was characterized by FTIR. Besides, the dispersant was applied in Shenfu coal slurry. Through examining properties of the coal slurry, the effects of amount of cationic monomer DMC, the concentration of initiator and reaction temperature on dispersant performance were discussed. The result shows that the viscosity reducing of amphoteric polycarboxylic dispersant is better than the dispersant in stock which hasn’t cationic monomer when the dosage of DMC is 5.0wt%. It has been proved that the amphoteric polycarboxylic dispersion agent is suitable for Shenfu coal slurry. When the dosage of AmPC dispersant is up to 0.5wt%, the highest concentration of coal-slurry can reach 65.4wt%.