A novel Ca/P-containing mesoporous silica-based xerogels (CaMSX) with good degradability and low heat generation were synthesized for hemorrhage control by a modified sol-gel process and physicochemically characterized. The mesoporous silica-based xerogels without Ca/P (MSX) was also prepared as comparison. The in vitro whole blood coagulation time, activated partial thromboplastin time (APTT) and prothrombin time (PT) of the CaMSX were measured with MSX, Chinese traditional medicin-Yunnan medical powder (YM) and traditional zeolite. In vivo bleeding model was tested with rabbit’ ear side veins. The results illustrated that the CaMSX could remarkably promote the intrinsic and extrinsic blood coagulation processes which greatly depend on the dosage and the content of Ca in the CaMSX. The CaMSX had better efficiency in promoting coagulation process than that of MSX, YM and zeolite.