Morphogenesis-Associated/Dissociated Production of Epothilone in Wild Sorangium Cellulosum Strains

Abstract:

To investigate the characters of Sorangium strains and the approaches for improving the production of epothilone, correlation of epothilone production and morphogenesis was studied in strains So0157-2, So0007-3 and So0003-3. On lean medium, So0157-2 could produce epothilones in a wide pH range (5.0-12.0), but formed fruiting bodies at high pH values (9.0-14.0). Formation of fruiting body did not affect the yield of epothilones in So0157-2. In So0007-3 and So0003-3, producing of epothilone was strongly coupled with the process of morphogenesis. It suggests that reduction of the association between morphogenesis and epothilone producing would prominently improve the epothilone production.

• Periodical: Advanced Materials Research (Volumes 343-344)
• Pages: 951-957
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.343-344.951
• Online since: September 2011
• Authors: Xin Li Liu, Lin Zhao, Wei Hu, Yue Zhong Li
• Keywords: Epothilone, Morphogenesis, Myxobacteria, Sorangium Cellulosum

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