Effect of Surfactant on Characteristics of Solid Lipid Nanoparticles (SLN)

Karn Orachai Kullavadee; Ruktanonchai Uracha; Siwaporn Meejoo Smith

doi:10.4028/www.scientific.net/AMR.364.313

Paper Titles

Fabrication of Photoelectrochemical Cell Using Highly Compact Vertical Array ZnO Nanorod
p.293

Effect of Electrolyte Composition in Electrochemical Synthesis of Self-Organized Tio₂ Nanotubes
p.298

Anodic Aluminum Oxide Templates for Nickel Nanowires Array Fabrication
p.303

Excitonic Contribution of Nanosilicon on Light Emitting Properties
p.308

Effect of Surfactant on Characteristics of Solid Lipid Nanoparticles (SLN)
p.313

Effect Addition of Octadecylamine Modified Clay (ODA-MMT) to Polylactide/Polycaprolactone (PLA/PCL) Blend
p.317

Characterization of SnO₂Nanoparticles Prepared by Two Different Wet Chemistry Methods
p.322

The Fabrication of Ag Islands on AlN/GaN/AlN/Si(111) by Using Thermal Evaporator and Thermal Annealing Methods
p.327

Growth Mechanism of Au-Catalyzed Zno Nanowires: VLS or VS-VLS?
p.333

HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 364Effect of Surfactant on Characteristics of Solid...

Effect of Surfactant on Characteristics of Solid Lipid Nanoparticles (SLN)

Abstract:

SLN have shown a great promise as an alternative drug carrier for intravenous and dermal applications. This work focuses on the basic properties of drug-free Compritol^® ATO 888 based SLN systems by using cationic surfactant (CPC) and nonionic surfactant (Tween 80). Effects of surfactant on the physical properties of SLNs were investigated in the absence of model drug to avoid the interaction between drug and surfactant. These SLN samples have different particle size, zeta potential and morphology. DSC was used to quantify the crystallinity of SLN systems. It was found that %RI of both SLNs was similar, indicating that types of surfactant did not affect on crystallization of solid lipid. Spherical-like particle was observed with SLN-C, while rod-like particle was found with SLN-T. The results demonstrated that surfactant plays an important role on SLN physical characteristics.