Targeting Human Telomeric G-Quadruplex with Perfluoroalkyl Metal Phthalocyanine Derivatives

Abstract:

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The ability of G-quadruplex ligands to induce formation of four-stranded DNA and stabilize four-stranded DNA make them able to inhibit telomerase. This paper investigated the interaction of four perfluoroalkyl phthalocyanine metal derivatives with telomeric DNA sequence 5’-d [TTAGGG)4TT-3’ by using circular dichrosim (CD), ultraviolet-visible and fluorescence spectroscopy, and molecular simulation method. Results show that perfluoroalkyl Zinic phthalocyanine can strongly induce the G-DNA in the buffer without extra K+/Na+ added with a molar ratio of 1:1 interaction possibly by intercalation into G-quartets, and only increases the amount of G-DNA in the presence of K+/Na+, with a compound/DNA 2:1 interaction possibly by external stacking model.

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Periodical:

Edited by:

Barry Tan

Pages:

382-388

DOI:

10.4028/www.scientific.net/AMR.365.382

Citation:

L. N. Liu et al., "Targeting Human Telomeric G-Quadruplex with Perfluoroalkyl Metal Phthalocyanine Derivatives", Advanced Materials Research, Vol. 365, pp. 382-388, 2012

Online since:

October 2011

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Price:

$35.00

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