Targeting Human Telomeric G-Quadruplex with Perfluoroalkyl Metal Phthalocyanine Derivatives

Abstract:

The ability of G-quadruplex ligands to induce formation of four-stranded DNA and stabilize four-stranded DNA make them able to inhibit telomerase. This paper investigated the interaction of four perfluoroalkyl phthalocyanine metal derivatives with telomeric DNA sequence 5’-d [TTAGGG)4TT-3’ by using circular dichrosim (CD), ultraviolet-visible and fluorescence spectroscopy, and molecular simulation method. Results show that perfluoroalkyl Zinic phthalocyanine can strongly induce the G-DNA in the buffer without extra K+/Na+ added with a molar ratio of 1:1 interaction possibly by intercalation into G-quartets, and only increases the amount of G-DNA in the presence of K+/Na+, with a compound/DNA 2:1 interaction possibly by external stacking model.

• Periodical: Advanced Materials Research (Volume 365)
• Pages: 382-388
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.365.382
• Online since: October 2011
• Authors: Li Nan Liu, Yan Ling Wu, Shi Kun Jiang, Tao Qiu, Hong Fei Zhang, Wen Zhang
• Keywords: Circular Dichroism (CD), Fluorescence Spectroscopy, Molecular Modeling, Perfluoroalkyl Metal Phthalocyanine, Telomeric G-Quadruplex

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