Targeting Human Telomeric G-Quadruplex with Perfluoroalkyl Metal Phthalocyanine Derivatives
The ability of G-quadruplex ligands to induce formation of four-stranded DNA and stabilize four-stranded DNA make them able to inhibit telomerase. This paper investigated the interaction of four perfluoroalkyl phthalocyanine metal derivatives with telomeric DNA sequence 5’-d [TTAGGG)4TT-3’ by using circular dichrosim (CD), ultraviolet-visible and fluorescence spectroscopy, and molecular simulation method. Results show that perfluoroalkyl Zinic phthalocyanine can strongly induce the G-DNA in the buffer without extra K+/Na+ added with a molar ratio of 1:1 interaction possibly by intercalation into G-quartets, and only increases the amount of G-DNA in the presence of K+/Na+, with a compound/DNA 2:1 interaction possibly by external stacking model.
L. N. Liu et al., "Targeting Human Telomeric G-Quadruplex with Perfluoroalkyl Metal Phthalocyanine Derivatives", Advanced Materials Research, Vol. 365, pp. 382-388, 2012