Fabrication of Hydroxyapatite and Observation of Nanoparticles Entering into Cells
Unambiguous and thorough knowledge of interactions between cells and nanoparticles was necessary for applications of nanoparticle in living system. In this report we presented systematic studies of fabrication of inorganic nanoparticles and the application of entering into cells. Size distribution, zeta potential and transmission electron microscope (TEM) were performed to characterize the nanoparticles structure and define the mechanism by which nanoparticles are capable of entering into cells. The study revealed nanoparticles can entered cells via penetrating through the lipophilic bilayer, which should be paid attention to for inspirational value insome application researches and will be harmful in other cases.
Helen Zhang and David Jin
D. Yang and E. J. Sun, "Fabrication of Hydroxyapatite and Observation of Nanoparticles Entering into Cells", Advanced Materials Research, Vol. 366, pp. 451-455, 2012