This paper discusses the design of the temperature and humidity monitoring system. It designs from software and hardware aspects in detail. The system included the three modules such as PC, FPGA and some peripheral circuit. Thereinto emphasis is laid on the introduction of hardware and software of communication interfaces of PC and FPGA. FPGA is core controller; PC is used to manage data acquisition and analysis. It introduces the data acquisition based on PXI bus and NI software LabVIEW. The system has the following advantages: its interface is friendly, its circuit is simple, its function is strong and its hardware system is integrated highly. The system realizes the monitoring the multi-humiture storehouses.