Preparation and Drug Release Properties of IBU-Loaded Mesoporous Calcium Silicate Hydrate (CSH) Spheres

Ya Dong; Hui Wen Yuan; Ya Ru Ni; Chun Hua Lu; Zhong Zi Xu

doi:10.4028/www.scientific.net/AMR.393-395.894

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 393-395Preparation and Drug Release Properties of...

Preparation and Drug Release Properties of IBU-Loaded Mesoporous Calcium Silicate Hydrate (CSH) Spheres

Abstract:

The novel kind flowerlike mesoporous spheres of calcium silicate hydrate (CaO•SiO2•H2O, CSH) have been synthesized by co-precipitation method on based with water/alcohol/calvital/ tetraethyl orthosilicate (TEOS) system. The synthesized CSH were applied as a carrier to study the loaded behaviors of ibuprofen(IBU),was used to investigate the drug loading behavior of the CSH for different times has been also discussed. The drug loading capacities(DLCs) of CSH loaded for 12h has reached 116.78wt.%. The structural, morphological and textural properties were investigated by SEM, FTIR, TG and BET. The results show that it would be a good candidate as drug carrier for bone repair.

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Advanced Materials Research (Volumes 393-395)

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894-897

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https://doi.org/10.4028/www.scientific.net/AMR.393-395.894

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Online since:

November 2011

Authors:

Ya Dong, Hui Wen Yuan, Ya Ru Ni, Chun Hua Lu, Zhong Zi Xu

Keywords:

Calcium Silicate Hydrate, Drug Carrier, Mesoporous

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