Preparation and Evaluation of the Pegylated Cerebrolysin

Hong Wei Wang; Zhong Wu Sun; Rong Hua Zhang

doi:10.4028/www.scientific.net/AMR.393-395.898

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 393-395Preparation and Evaluation of the Pegylated...

Preparation and Evaluation of the Pegylated Cerebrolysin

Abstract:

Four kinds of brain active peptide (BAP) in Cerebrolysin were effectively modified by mPEG-ALD5000 of single molecule. At pH = 5.0, 25°C, with Cerebrolysin (injection)/mPEG-ALD5000 feed ratio of 5 mL : 1 g, the modification rate reached 72.805% after 30 min. The method of nerve cells culture in vitro was used to evaluate the biological activity of modified Cerebrolysin. The result showed that after the BAPs in Cerebrolysin were modified by mPEG-ALD5000, the activity of promoting nerve cell growth of Cerebrolysin was significantly improved.

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Periodical:

Advanced Materials Research (Volumes 393-395)

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898-901

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.393-395.898

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Online since:

November 2011

Authors:

Hong Wei Wang, Zhong Wu Sun, Rong Hua Zhang

Keywords:

Biological Activity, Cerebrolysin, Pegylation

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