Drug Release Characteristics of P(AA-co-DMAA)/SA Interpenetrating Polymer Network Hydrogels

Na Na Wang; Song Bai Lin; Ke Ping Wang; Ai Ru Ke

doi:10.4028/www.scientific.net/AMR.399-401.1165

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 399-401Drug Release Characteristics of P(AA-co-DMAA)/SA...

Drug Release Characteristics of P(AA-co-DMAA)/SA Interpenetrating Polymer Network Hydrogels

Abstract:

P(AA-co-DMAA) superporous drug-loaded hydrogels containing berberine hydrochloride were prepared by dispersion polymerization in foam system with acrylic acid (AA) and N,N-dimethyl acrylamide (DMAA) as monomers. Then sodium alginate (SA) as the second network was added to the system, and P(AA-co-DMAA)/SA interpenetrating polymer network (IPN) hydrogels were formed. The effects of pH value, reaction time between SA and glutaric dialdehyde (GA), the concentration of SA and GA on release behavior of berberine hydrochloride were discussed. The FT-IR spectra showed that P(AA-co-DMAA)/SA IPN hydrogels were synthesized successfully. The inverted fluorescence micrograph of P(AA-co-DMAA)/SA showed that some part of the superporous structures were still retained.The cumulative release proﬁles showed that the release rates were slightly higher in pH=6.8 phosphate buffer solution (PBS) than the one in pH=1 HCl solution. The release rate was the slowest in distilled water, only 7.3% within 24h. When the reaction time between SA and GA was shortened, the release speed of berberine hydrochloride became faster. The pore size of P(AA-co-DMAA) hydrogels was reduced with the concentration of SA and GA increased, and the release rate decreased due to the more dense network structures.

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Periodical:

Advanced Materials Research (Volumes 399-401)

Pages:

1165-1168

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.399-401.1165

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Online since:

November 2011

Authors:

Na Na Wang, Song Bai Lin, Ke Ping Wang, Ai Ru Ke

Keywords:

Berberine Hydrochloride, IPN Hydrogel, Release

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