A pH-Sensitive Poly (2-(Acryloyloxy) Propanoic Acid) Hydrogel and its Drug Release Behaviors

Abstract:

A novel pH-sensitive poly (2-(acryloyloxy) propanoic acid) hydrogel (PAPA) synthesized from lactic acid by radical polymerization has been investigated in this work. The structure of prepared monomer 2-(acryloyloxy) propanoic acid) (APA) has been characterized by FTIR and ¹H-NMR measurements. PAPA hydrogel demonstrated an obvious pH sensitivity in its swelling in the range of 4-7 pH of phosphate buffer solution (PBS). The rapid response of the hydrogel makes it suitable for drug delivery application. Here, salicylic acid (SA) selected as a model drug, the in-vitro drug release as a function of pH and temperature was studied systematically. The cumulative release of salicylic acid reached up to 86.6% in pH=7.4 PBS at 37.0°C within 550min. In pH=2.1 PBS, however, only 26.6% drug was released from the pH-sensitive PAPA on the same conditions.

• Periodical: Advanced Materials Research (Volumes 455-456)
• Pages: 901-906
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.455-456.901
• Online since: January 2012
• Authors: Kui Lin Deng, Chun Yuan Huang, Xiao Bo Ren, Yu Bo Gou, Hai Bin Zhong, Peng Fei Zhang, Chun Yan Jiang
• Keywords: Drug Release, Hydrogel, pH Senstitive, Poly(2-(Acryloyloxy) Propanoic Acid)

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