Construction of Nonbiofouling Biofunctional Glass Surface by Self-Assembled Monolayer and Graft Hydrophilic Polymer

Zong Bin Liu; Bei Zhang; Brian Yu Fung Pow; Mo Yang; Arthur Fuk Tak Mak

doi:10.4028/www.scientific.net/AMR.47-50.1343

Paper Titles

Distinctive Degradation Behaviors of Electrospun PGA, PLGA and P(LLA-CL) Nanofibers Cultured with/without Cell Culture
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A Retrievable Polymer Urethral Stent for Treatment of Urethral Strictures
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Activation of MAPK and NF-κB Induced by Biomaterials in Vascular Endothelial Cells
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An Evaluation of CaF₂ Doping Tricalcium Silicate as Dental Restorative Materials
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Construction of Nonbiofouling Biofunctional Glass Surface by Self-Assembled Monolayer and Graft Hydrophilic Polymer
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Poly(L-Lactide)/Multiwalled Carbon Nanotube Composites: Interaction with Osteoblast-Like Cells In Vitro
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In Vitro Bioactivity of Potassium Titanate Whiskers
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Kinetic Effect of Cationic Comb-Type Copolymers on DNA Hybridization
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Bio-Fabrication of Patterned Cellulose Nano-Fibers
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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 47-50Construction of Nonbiofouling Biofunctional Glass...

Construction of Nonbiofouling Biofunctional Glass Surface by Self-Assembled Monolayer and Graft Hydrophilic Polymer

Abstract:

This paper introduces a new method of surface modification by self-assembled monolayer (SAM) and polymer monolayer grafting. Since most of the glass surfaces lack the reactive functional group, an activation process with 3-(trimethoxysilyl)propyl methacrylate(TPM) is used in our experiment to generate the vinyl reactive sites on the substrate surface for further graft polymerization. The TPM saline layer acts as the “anchor” part to link the functional part onto the surface of substrate. The paper summarizes the surface modifications by the polymerizations of PEGMA, AA(Acrylic acid) and NVP(Nitrogen-vinyl-2-pyrrolidone) respectively and their applications for protein adsorption and cell adhesion through a series of measurements. In previous research, AA and NVP had also been adopted for surface treatment and had achieved good results. The substrate can be glass, alumina, silicon, metals or stainless steel. We choose glass as our substrate during the experiment.