Kinetic Effect of Cationic Comb-Type Copolymers on DNA Hybridization

Abstract:

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We have been interested in the soluble interpolyelectrolyte complexes (IPEC) between DNA and the cationic comb-type copolymers, poly(L-lysine)-graft-dextran (PLL-g-Dex), consisting of a polylysine backbone and abundant hydrophilic graft chains of dextran as a model of nucleic acid-binding proteins. In this paper, we described the kinetic effect of the copolymers on the DNA hybridization. We found that the cationic copolymer at nano molar concentrations in cationic groups accelerated DNA duplex formation by two orders under physiologically relevant conditions.

Info:

Periodical:

Advanced Materials Research (Volumes 47-50)

Edited by:

Alan K.T. Lau, J. Lu, Vijay K. Varadan, F.K. Chang, J.P. Tu and P.M. Lam

Pages:

1355-1358

DOI:

10.4028/www.scientific.net/AMR.47-50.1355

Citation:

A. Maruyama et al., "Kinetic Effect of Cationic Comb-Type Copolymers on DNA Hybridization", Advanced Materials Research, Vols. 47-50, pp. 1355-1358, 2008

Online since:

June 2008

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$35.00

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