Kinetic Effect of Cationic Comb-Type Copolymers on DNA Hybridization
We have been interested in the soluble interpolyelectrolyte complexes (IPEC) between DNA and the cationic comb-type copolymers, poly(L-lysine)-graft-dextran (PLL-g-Dex), consisting of a polylysine backbone and abundant hydrophilic graft chains of dextran as a model of nucleic acid-binding proteins. In this paper, we described the kinetic effect of the copolymers on the DNA hybridization. We found that the cationic copolymer at nano molar concentrations in cationic groups accelerated DNA duplex formation by two orders under physiologically relevant conditions.
Alan K.T. Lau, J. Lu, Vijay K. Varadan, F.K. Chang, J.P. Tu and P.M. Lam
A. Maruyama et al., "Kinetic Effect of Cationic Comb-Type Copolymers on DNA Hybridization", Advanced Materials Research, Vols. 47-50, pp. 1355-1358, 2008