Development of Core-Crosslinked Micelles for Drug Delivery System

Yue Zhao; Ming Tao Liang; Yoseop Kim; Xin Tan; Ling Zhang; Martina H. Stenzel

doi:10.4028/www.scientific.net/AMR.486.449

Paper Titles

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Spectrometric Radiation Measurements of Nanoporous Insulation Materials
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Preparation of Z-Pin from Different Resin and Evaluation of Interlaminar Reinforcement Effect by Pullout Test
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Development of Core-Crosslinked Micelles for Drug Delivery System
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Research and Development of a New Type of Water-Based Drilling Fluid
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A New Method of On-Line Fault Monitoring Based on Nonlinear MPCA
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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 486Development of Core-Crosslinked Micelles for Drug...

Development of Core-Crosslinked Micelles for Drug Delivery System

Abstract:

A polymer drug delivery system was developed using crosslinked self-assembled micelles, which form stable coreshell particles. The block copolymer, composed of poly [poly (ethylene glycol) methyl ether methacrylat-block-[poly (methyl methacrylate-p-nitrophenyl acrylate)] [P(PEGMEMA)-b-P(MMA-NPA)], was synthesized via reversible addition fragmentation chain transfer (RAFT) polymerization. The self-assembled micelles were stabilized by core crosslinking through the reaction of p-nitrophenyl acrylate with 1,8-octandiamine forming stable coreshell particles.

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Periodical:

Advanced Materials Research (Volume 486)

Pages:

449-454

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.486.449

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Online since:

March 2012

Authors:

Yue Zhao, Ming Tao Liang, Yoseop Kim, Xin Tan, Ling Zhang, Martina H. Stenzel

Keywords:

Crosslinked Micelles, Drug Delivery, Reversible Addition Fragmentation Chain Transfer (RAFT) Polymerization

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