Preparation of Cortex Moutan Nanoparticles and its Microscopic Characteristics and Physicochemical Properties

Abstract:

Objective In order to increase the Paeonol dissolution and content, cortex moutan were smashed into nanoparticles, and the dissolution and content were compared by microscopy before and after super-micro-particle pulverization. Methods Super-micro-particle pulverization and general grinding were used to broke Cortex moutan into particles. The microscopic morphous characteristics of the before- and after- ultra-disintegration particles were compared by microscopy. Methods of HPLC was used to determine the content and dissolution of Paeonol with different grinding conditions. Methods of precipitation and funnel way were used to examine the stability and fluidity of cortex moutan nano-particles. Results Cortex moutan powder after super-micro-particle pulverization appears sphere or like-sphere, and its average size is 200nm~300nm. After the superfine grinding Paeonol dissolution increases 76.19% in comparison with without nano pulverization. The nanoparticle rest angle is θ=33°.The precipitation ratio of Cortex moutan powder with general grinding is 0.28 at 24h, and the precipitation ratio of its nano-power has been to 0.98 at 60min. Conclusion Paeonol dissolution, stability and fluidity of Cortex moutan nanoparticles were improved greatly and this nanoparticles is beneficial to industrial production for traditional Chinese medicine.

• Periodical: Advanced Materials Research (Volume 528)
• Pages: 54-57
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.528.54
• Online since: June 2012
• Authors: Yu Jia Cui, Wei Guo Wang, Peng Li, Yong Liang Zhao, Ya Nan Gu, Tian Tian Meng, Jin Ju Ding, Peng Zhang, Ke Jia
• Keywords: Cortex Moutan, Dissolution, Fluidity, Paeonol, Stability, Super-Micro-Particle Pulverization

References

[1] YM Xue, R Luo, B Zhu, Y Zhang, YH Pan, and CZ Li. Liuweidihuang pills reduces vis-ceral fat deposition in Otsuka Long-Evans Tokushima Fatty rats, J. Nan Fang Yi Ke Da Xue Xue Bao. Oct 2006,26(10): 1446-8.

[2] Silanpaaer J, Al-Dhahir, Gillard R D. Bispaeonolimina to copper(Ⅱ), J. Polyhedron. 1999, 10(17): 2051-2055.

[3] Xu H B, Yang X L, Xie C S, et al. The application of nanotechnology on traditional Chinese drug, J. China Pham. 2001,32 (3): 161-162.

[4] Xie C S, Yang X L, Xu H B. Preparation of nanomagnet, P. CN:00116045.1, 2000-09-25.

[5] Contamin E F, Fai D F, Wihelivia M, et al. Chemical reactions under ultrasound: discrimination of Chemical and physical effects, J. Chem Eng Sci. 1994,49(24B): 5865-5873.

[6] Mathiowitz E, Jacob J S, Jong Y S. Carino G P. Biologically erodable microspheres as potential oral drug delivery systems, J. Nature. 1997, 386: 410-414.

DOI: 10.1038/386410a0

[7] Gibaud S, Rousseau C, Weingarten C, et al. Polyalkylcyanoacrylate nanoparticles as carriers for granulocyte colony stimulating factor(G-CSF), J. Control Release. 1998,52: 131-139.

DOI: 10.1016/s0168-3659(97)00194-6

[8] Cho C S, Kobayashi A, Takei R, et al. Receptor-mediated cell modulator delivery to hepatocyte using nanoparticles coated with carbohydrate-carrying polymers, J. Biomaterials. 2001, 22: 45-51.

DOI: 10.1016/s0142-9612(00)00143-5