Preparation and Characterization of Chitosan-Poly(MA-PEG400-SA) Nanoparticles as Drug Carrier

Dan Zhang; Fei Qiu; Yong Diao

doi:10.4028/www.scientific.net/AMR.528.39

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 528Preparation and Characterization of...

Preparation and Characterization of Chitosan-Poly(MA-PEG₄₀₀-SA) Nanoparticles as Drug Carrier

Abstract:

In order to prepare chitosan-based nanoparticles for drug delivery, we synthesis chitosan-poly(methacryloyl polyethylene glycol succinic acid, MA-PEG400-SA) nanoparticles in aqueous solution via template polymerization. The structure of the chitosan-poly(MA-PEG400-SA) nanoparticles was characterized by FT-IR spectra, and the particles size and surface charge were analyzed by zetasizer, respectively. The average size of chitosan-poly(MA-PEG400-SA) nanoparticles was approximate 325 nm, and the surface charge was 33mv. Using hydrophilic drug 5-FU as the model drug, the drug loading efficiency was about 6%. In the further study, we will optimize the synthesis conditions and study on the drug release properties of the nanoparticles.

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Periodical:

Advanced Materials Research (Volume 528)

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39-42

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.528.39

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Online since:

June 2012

Authors:

Dan Zhang, Fei Qiu, Yong Diao

Keywords:

Chitosan, Drug Carrier, Nanoparticle, Poly(MA-PEG₄₀₀-SA), Polymerization

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