Study the Biodegradation of a Injection Human-Like Collagen Hydrogel

Abstract:

In this paper, the cross-linking hydrogels were synthesized by EDC crosslinker and Carboxymethyl chitosan (CMCS)/Human-like collagen (HLC). The morphology of the hydrogels was observed by scanning electron microscope (SEM). The important performance of these hydrogels is biodegradation which was assessed in two ways: (1) Through enzyme solution experiment in vitro , investigating in vitro degradation property. (2) Injecting the hydrogels to mice subcutaneous , after 2,4,12,and 24 weeks of healing ,the rats were sacrificed and explanted specimens were prepared for histology analysis. Investigating degradation time in vitro and in vivo , and studying the histology .HLC hydrogels degradation time gets eight to ten months, in addition has good compatibility of the histological performances. The hydrogels are promised for the applications in the biomaterials area.

• Periodical: Advanced Materials Research (Volumes 535-537)
• Pages: 2291-2295
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.535-537.2291
• Online since: June 2012
• Authors: Yu Zhang Du, Dai Di Fan, Xiao Xuan Ma, Chen Hui Zhu, Li Jun Zhang
• Keywords: Biodegradation, Carboxymethyl Chitosan, Human-Like Collagen, Hydrogel

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