Single Crystal X-Ray Structural Determination: A Powerful Technique for Natural Products Research and Drug Discovery

Hoong Kun Fun; Suchada Chantrapromma; Nawong Boonnak

doi:10.4028/www.scientific.net/AMR.545.3

Paper Titles

Single Crystal X-Ray Structural Determination: A Powerful Technique for Natural Products Research and Drug Discovery
p.3

TEM and SEM Analysis for Formation Mechanism of Tin Whiskers
p.16

Functional Films of Polymer-Nanocomposites by Electrospinning for Advanced Electronics, Clean Energy Conversion, and Storage
p.21

Nanostructured A₂(RE,B)O₆ (A = Ba, Sr; RE = Rare-Earth; B = Sb, Zr) Perovskite Ceramics and their Potential Applications in Microwave and Superconducting Electronics
p.27

Optical Properties of Si Quantum Dot Potential under Pressure Effect
p.32

Pulsed LASER Deposition of MgO Thin Films
p.38

Quasicrystal Surfaces: Structure, Adsorption and Epitaxy
p.43

Combustion Synthesis of Ni/Al Base Composites
p.50

HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 545Single Crystal X-Ray Structural Determination: A...

Single Crystal X-Ray Structural Determination: A Powerful Technique for Natural Products Research and Drug Discovery

Abstract:

Drug discovery from natural products resources have been extensively studied. The most important step in the discovery process is the identification of compounds with interesting biological activity. Single crystal X-ray structure determination is a powerful technique for natural products research and drug discovery in which the detailed three-dimensional structures that emerge can be co-related to the activities of these structures. This article shall present (i) co-crystal structures, (ii) determination of absolute configuration and (iii) the ability to distinguish between whether a natural product compound is a natural product or a natural product artifact. All these three properties are unique to the technique of single crystal X-ray structure determination.

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Periodical:

Advanced Materials Research (Volume 545)

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3-15

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.545.3

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Online since:

July 2012

Authors:

Hoong Kun Fun, Suchada Chantrapromma, Nawong Boonnak

Keywords:

Absolute Configuration, Chromene Ring, Co-Crystal, Crystal Structure, Cyclization, Disorder, Gerontoxanthone, Macluraxanthone, Natural Products, Non-Enzymatic Product

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