Research Progress on Curcumin Prodrugs

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Abstract:

In this paper, the status and research progress of curcumin prodrugs were reviewed, involving polyethylene glycol(PEG) loading prodrug, cholesterol loading prodrug, surfactant like amphiphilic loading prodrug, curcumin-amino acid bioconjugates, which provided basis for the further development of curcumin.

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Advanced Materials Research (Volumes 554-556)

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1857-1860

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July 2012

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© 2012 Trans Tech Publications Ltd. All Rights Reserved

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[1] Preetha Anand, Sherin G. Thomas, Ajaikumar B. Kunnumakkara, et al. Biological activities of curcumin and its analogues(Congeners) made by man and Mother Nature [J]. Biochemical Pharmacology, 2008, 76: 1590-1611.

DOI: 10.1016/j.bcp.2008.08.008

Google Scholar

[2] Ruby AJ, Kuttan G, Babu KD, et al. Anti-tumour and antioxidant activity of natural curcuminoids [J]. Cancer Letters, 1995, 94(1): 79-83.

DOI: 10.1016/0304-3835(95)03827-j

Google Scholar

[3] Joe B, Vilaykumar M, Lokesh BR. Biological properties of curcumin-cellular and molecular mechanisms of action [J]. Crit Rev Food Sci Nutr, 2004, 44(2): 97-111.

DOI: 10.1080/10408690490424702

Google Scholar

[4] Apparao Satyam, Mumbai. Prodrug containing novel bio-cleavable linkers [P]. US 20060046967, 2006-03-02.

Google Scholar

[5] CAI Rui-hong. The synthesis and characterization of curcumin bonded with polyethylene glycol [D]. Fujian, fuzhou, Fujian Medical University: 2007. In Chinese.

Google Scholar

[6] Takeshita K, Okazaki S, Kansui H. Effect of cholesterol on distribution of stable, hydrophobic perchlorotriphenylmethyl triethylester radical incorporated in lecithin liposomal membranes [J]. Chem Pharm Bull, 2011, 59(5): 624-628.

DOI: 10.1248/cpb.59.624

Google Scholar

[7] G.F. Peacock, B. Ji.C. K, Wang D.R. Lu. Cell Culture Studies of a Carborane Cholestery Ester With Conventional and PEG Liposomes [J]. Drug Delivery, 2003, 10: 29-34.

DOI: 10.1080/713840324

Google Scholar

[8] YU Mei-rong, LIU-Xia, XU Fan-fan, etc. Cholesterol-curcumin prodrug synthesis and preliminary research of its anti-tumor effects[C]. Symposium for Annul Conference of Zhejiang Association for Chinese Medicine, Chinese Electronic Press for Academic Journal,2009:55-62. In Chinese.

Google Scholar

[9] Bisht S, Feldmann G, Soni S, et al. Polymeric nanoparticle-encapsulated curcumin (nanocurcumin, ): a novel strategy for human cancer therapy [J]. Nanobiotechnol. 2007, 5: 1–18.

DOI: 10.1186/1477-3155-5-3

Google Scholar

[10] Shi W, Dolai S, Rizk S. et al. Synthesis of monofunctional curcumin derivatives, clickedcurcumin dimer, and a PAMAM dendrimer curcumin conjugate for therapeutic applications [J]. Org Lett. 2007, 9: 5461–5464.

DOI: 10.1021/ol702370m

Google Scholar

[11] Safavy A, Raisch KP, Mantena S, et al. Design and development of water-soluble curcumin conjugates as potential anticancer agents [J]. J. Med. Chem. 2007, 50: 6284–6288.

DOI: 10.1021/jm700988f

Google Scholar

[12] Huadong Tang, Caitlin J Murphy, Bo Zhang, et al. Amphiphilic curcumin conjugate-forming nanoparticles as anticancer prodrug and drug carriers: in vitro and in vivo effects [J]. Nanomedicine. 2010, 5(6): 855-865.

DOI: 10.2217/nnm.10.67

Google Scholar

[13] Maeda H, Wu J, Sawa T, Matsumura Y, et al. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review [J]. J. Control. Release, 2000, 65: 271–284.

DOI: 10.1016/s0168-3659(99)00248-5

Google Scholar

[14] Saijo, Y., Perlaky, L., Wang, H., et al. Pharmacokinetics, tissue distribution, and stability of antisense oligodeoxynucleotide phosphorothioate ISIS 3466 in mice [J]. Oncol. Res. 1994, 6(6): 243-249.

Google Scholar

[15] Marzo, A. L., Fitzpatrick, D. R., Robinson, B. W. S., et al. Antisense Oligonucleotides Specific for Transforming Growth Factor β2 Inhibit the Growth of Malignant Mesothelioma Both in Vitro and in Vivo [J]. Cancer Res. 1997, 57: 3200-3207.

DOI: 10.1016/0169-5002(96)81643-6

Google Scholar

[16] Díaz J, Díaz MM, Pastene L. et al. Randomized clinical study of the T-Cu 380A and the Lippes Loop C, in Campinas, Brazil [J]. Contraception 1982; 26: 221-228.

DOI: 10.1016/0010-7824(82)90071-3

Google Scholar

[17] Lee, E. B., Shin, K. H., Woo, W. S. Combined effects of curcumin and piperine in ameliorating benzo(a)pyrene induced DNA damage [J]. Arch. Pharmacal. Res. 1984, 7, 127.

Google Scholar

[18] Satyendra Mishra, Upma Narain, Roli Mishra, et al. Design, development and synthesis of mixed bioconjugates of piperic acid-glycine, curcumin-glycine/alanine and curcumin-glycine–piperic acid and their antibacterial and antifungal properties [J]. Bioorganic & Medicinal Chemistry 13 (2005).

DOI: 10.1016/j.bmc.2004.12.057

Google Scholar