Synthesis of α-Alkyltetronic Acids

Abstract:

Tetronic acid, namely 4-hydroxy-2(5H)-furanone, was prepared from ethyl acetoacetate by bromination at γ position followed by hydrolysis and cyclization in aqueous NaOH solution. Using ethyl α-alkylacetoacetate afforded by alkylation of ethyl acetoacetate as starting material, four α-alkyltetronic acids were synthesized. Optimization of the reaction conditions led to total yield of more than 64%.

• Periodical: Advanced Materials Research (Volumes 554-556)
• Pages: 1861-1864
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.554-556.1861
• Online since: July 2012
• Authors: Hong Ji, Tao Dai, Mu Yuan, Liu Zhu, Biyun Huang
• Keywords: Ethyl γ-Bromoacetoacetate, Synthesis, Α-Alkyltetronic Acid

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