The Preparation and Research of β-Chitosan/HA Composite Magnetic Microspheres

Li Peng Gu; Xiao Qing Peng; Chen Jiang; Chang Chun Zhao

doi:10.4028/www.scientific.net/AMR.557-559.767

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 557-559The Preparation and Research of β-Chitosan/HA...

The Preparation and Research of β-Chitosan/HA Composite Magnetic Microspheres

Abstract:

In this work, we demonstrate β-Chitosan(βCS) made from the skin of maggot has higher viscosity, better activity and lower heavy metal concentration in comparison with α-Chitosan made from shrimp shell and crab shell. This study is basedon hydroxyapatite(HA) as the matrix. The method of reverse phase suspension cross-linking was adopted in the experiment to prepare Fe₃O₄/βCS magnetic microspheres. Then magnetic Fe₃O₄/βCS/HA composite microspheres were prepared by compounding Fe₃O₄/βCS with HA via in situ precipitation method. Through our experiments, we found the concentration of βCS 1.5%, Fe₃O₄/βCS mass ratio of 9.05, and stirring speed of 1200r/min to be the optimal conditions. Furthermore, the structure and morphology of β-magnetic chitosan microspheres were analyzed with XRD and SEM, and the average particle diameters were determined to be 10μm. With the productivity of β-magnetic chitosan microspheres is above 50%, the magnetic Fe₃O₄/βCS/HA composite microspheres are expected to become promising multi-functional bone repair materials.

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Periodical:

Advanced Materials Research (Volumes 557-559)

Pages:

767-771

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.557-559.767

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Online since:

July 2012

Authors:

Li Peng Gu, Xiao Qing Peng, Chen Jiang, Chang Chun Zhao

Keywords:

Hydroxyapatite (HAP), Magnetic Microspheres, β-Chitosan

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