Preparation of N, O-carboxymethyl chitosan-Human-Like Collagen Microspheres for Drug Delivery

Pei Ma; Ran Su; Dai Di Fan

doi:10.4028/www.scientific.net/AMR.560-561.410

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 560-561Preparation of N, O-carboxymethyl...

Preparation of N, O-carboxymethyl chitosan-Human-Like Collagen Microspheres for Drug Delivery

Abstract:

In this investigation, the N, O-carboxymethyl chitosan (NOCC) was synthesized. A novel pH-sensitive hydrogel system composed of a water-soluble chitosan derivative (N,O-carboxymethyl chitosan, NOCC)and Human-like collagen (HLC) blended with phosphate was developed for controlling drug delivery and NOCC–HLC microspheres were prepared by the technology of electrostatic droplet generation technique. The release profiles of a model protein drug (bovine serum albumin, BSA) from test hydrogels were studied in simulated gastric and intestinal media.

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Periodical:

Advanced Materials Research (Volumes 560-561)

Pages:

410-414

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.560-561.410

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Online since:

August 2012

Authors:

Pei Ma, Ran Su, Dai Di Fan

Keywords:

CS, HLC, Micro-Sphere, NOCC

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References

[1] S. C. Chen, Y. C. Wu, F. L. Mi, Y. H. Lin, L. C. Yu, H. W. Sung, A novel pH-sensitive hydrogel composed of N, O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery, Journal of Controlled Release. 96 (2004).

DOI: 10.1016/j.jconrel.2004.02.002

Google Scholar

[2] C. P. Champagne, F. Girard, and N. Rodrigue, Production of concentrated suspensions of thermophilic lactic acid bacteria in calcium-alginate beads, Int. Dairy J. 3 (1993) 257-275.

DOI: 10.1016/0958-6946(93)90068-b

Google Scholar

[3] J. S. Lee, D. S. Cha and H. J. Park, Survival of Freeze-Dried Lactobacillus bulgaricus KFRI 673 in Chitosan-Coated Calcium Alginate Microparticles, J. Agric. Food Chem. 52 (2004) 7300-7305.

DOI: 10.1021/jf040235k

Google Scholar

[4] R. Su, X. L. Zhu, D. D. Fan, Y. Mi, C. Y. Yang and X. Jia, Encapsulation of probiotic Bifidobacterium longum BIOMA 5920 with alginate–Human-like collagen and evaluation of survival in simulated gastrointestinal conditions, International Journal of Biological Macromolecules. 49 (2011).

DOI: 10.1016/j.ijbiomac.2011.08.018

Google Scholar

[5] I. M, El-Sherbiny, Enhanced pH-responsive carrier system based on alginate and chemically modified carboxymethyl chitosan for oral delivery of protein drugs: Preparation and in-vitro assessment, Carbohydrate Polymers. 80 (2010) 1125–1136.

DOI: 10.1016/j.carbpol.2010.01.034

Google Scholar

[6] Lingyun Chen, Muriel Subirade, Chitosan/b-lactoglobulin core–shell nanoparticles as nutraceutical carriers. Biomaterials 26(2005)6041–6053.

DOI: 10.1016/j.biomaterials.2005.03.011

Google Scholar