Preparation and Characterization of Cefradine/Montmorillionite Composites

Lan  Wang; Wen Ji Guo; Yan Zhao Zhao

doi:10.4028/www.scientific.net/AMR.560-561.434

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 560-561Preparation and Characterization of...

Preparation and Characterization of Cefradine/Montmorillionite Composites

Abstract:

The objective of this paper was to prepare the composite of crefradine/montmorillionite in the method of solution intercalation. The drug load and intercalation rate varied with the drug concentration. X-ray diffraction (XRD), Fourier transformed infrared (FT-IR) Spectroscopy, and thermal analysis (TG-DSC) were applied to characterize composite mentioned above. Together with drug release tests, results indicate cefradine intercalated into montmorillionite.The release profiles of cefradine/MMT in simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 7.4) at 37°Cduring 10h are shown in Fig. 4. The amount of cefradine in the beginning 2h came up to 35% and 50%, and in the following time, cefradine released slowly. The release behaviors met the requirements of sustained release.

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Advanced Materials Research (Volumes 560-561)

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434-437

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https://doi.org/10.4028/www.scientific.net/AMR.560-561.434

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Online since:

August 2012

Authors:

Lan Wang, Wen Ji Guo, Yan Zhao Zhao

Keywords:

Cefradine, Composite, Drug Release, Montmorillionite

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