Spectrophotometric Determination of Kryptofix 2.2.2 Using TCNQ

Mu Yi He; Li Quan Sun; Ai Qin Luo

doi:10.4028/www.scientific.net/AMR.581-582.1156

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 581-582Spectrophotometric Determination of Kryptofix...

Spectrophotometric Determination of Kryptofix 2.2.2 Using TCNQ

Abstract:

The interactions of the electron donors kryptofix (K-222) with 7,7,8,8-Tetracyanoquino- dimethane (TCNQ) were studied spectrophotometrically in aceton/water at several temperatures. The UV-vis spectra of the formed molecular charge transfer (CT) complexes were recorded. The molecular structures of the CT-complexes were independent of the position of the amino group on the K-222 and were formulated as [(K-222)(TCNQ)]. A spectrophotometric method for determination of K-222 was developed and validated for the quantitative analysis of K-222 in the radiopharmaceuticals. With an internal standard, the limit of quantitation for K-222 was 2 ug/ml. This is so far the most facile method for the determination of K-222. Excellent linearity (RSQ = 0.9997) was obtained over the range of 2.0–31 ug/ml. Good precision and accuracy were also observed. The method is amenable to the validation of radiosynthetic methods.

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Periodical:

Advanced Materials Research (Volumes 581-582)

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1156-1159

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https://doi.org/10.4028/www.scientific.net/AMR.581-582.1156

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October 2012

Authors:

Mu Yi He, Li Quan Sun, Ai Qin Luo

Keywords:

Kryptofix 2.2.2, Spectrophotometry, TCNQ

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